mod_rewrite?

Rewrites the requested URL on-the-fly based on configuration directives and rules.
You are using system paths. Apache mod_rewrite only works with URLs,
 
RewriteEngine On
RewriteBase /
RewriteCond %{REQUEST_FILENAME} !-f
RewriteCond %{REQUEST_FILENAME} !-d
RewriteCond %{REQUEST_URI}  !^(favicon\.ico|assets)  [NC]
RewriteRule  ^(.*)/?$    DestinationFolder/$1        [L]